Citrulline, checked
L-citrulline for brain health: what is actually known?
L-citrulline for brain health has no direct human trial that we found. The closest is a 12-athlete study of a mix of three amino acids, which cannot isolate citrulline. MemoHoney lists two citrulline rows, 200 mg in total. Exercise trials used 3 to 9 g a day, about 15 to 45 times more.
Written by the MemoHoney label deskUpdated · 5 min read
Is there a human trial of L-citrulline for brain health?
No, we found no human trial of L-citrulline or citrulline malate on memory or thinking in ordinary adults.
The closest item is a small study of 12 male taekwondo athletes. After simulated matches they took a mix of BCAA, arginine and citrulline or placebo. Reaction time held up with the mix and fell with placebo (Chen 2016, BCAA arginine citrulline). Because three ingredients were given together, it cannot show what citrulline did alone, and the athletes were fatigued, not older adults.
Does citrulline reach the brain through blood flow?
Citrulline is turned into arginine in the body, and arginine feeds nitric oxide, but nobody has shown that this raises brain blood flow from a capsule.
A physiology review calls nitric oxide an important regulator of brain circulation (Toda 2009, NO and brain blood flow). That describes a mechanism. It does not say that swallowing amino acids changes blood flow in the brain or improves memory. Reviews of muscle blood flow call the evidence for citrulline "scarce and inconsistent".
How strong is the evidence for each MemoHoney ingredient?
For citrulline, the evidence meter reads "none shown" for memory, focus or brain blood flow.
The bars score each ingredient from 0 to 4 on that question. They rate the evidence, not the product.
| Item | Amount | Note |
|---|---|---|
| L-citrulline HCl | 100 mg | Printed on the label |
| L-citrulline malate | 100 mg | Malate is a salt; about 56.6% is citrulline |
| Exercise and blood pressure trials | 3 to 9 g a day | Not memory trials |
MemoHoney capsules: 30 to a bottleOne capsule a day · 2, 3 or 6 bottles · price and shipping shown at checkout
See the priceWhat does this mean for the MemoHoney capsule?
It means the citrulline rows in MemoHoney have no memory trial behind them, and 200 mg is far below what exercise studies used.
MemoHoney is a dietary supplement, not a drug, and contains no honey. Short studies up to 6 g a day found no adverse effects, but stomach discomfort occurred in 6 of 41 people in one study (NIH ODS, exercise supplements). Ask your doctor or pharmacist if you take nitrates or blood pressure medicines, and keep taking prescribed medicine. Memory problems that are new or getting worse need a clinician. See the L-citrulline page.
Can you still order it if you are curious?
You can, through the seller's checkout, where the total is shown before you pay.
Nothing here promises a result. Packs of 2, 3 and 6 bottles are shown in the seller's images; confirm at checkout.
90-day supply
3 bottles: 90 days
90 capsulesone a day · price shown at checkout
Shipping at checkout · Guarantee as printed there
See 3 bottles
180-day supply
6 bottles: 180 days
180 capsulesone a day · price shown at checkout
Shipping at checkout · Guarantee as printed there
See 6 bottlesPrices are shown at checkout (MemoHoney sales site). Two bottles are also sold. Check your medicines with your doctor or pharmacist before you order.
FAQ
MemoHoney questions people ask
Is L-citrulline good for the brain?
We found no human trial showing it. The closest study mixed citrulline with two other ingredients in 12 athletes. Citrulline is used by the body to make arginine, but the label's 200 mg across two rows has no memory study behind it.
What is citrulline malate?
It is citrulline bound to malate, a salt, and it is about 56.6% citrulline by weight. MemoHoney lists 100 mg of citrulline malate and 100 mg of citrulline HCl per capsule. Exercise trials used 3 to 9 g a day of citrulline products.
Does citrulline cognition research exist?
Very little. Citrulline cognition work is limited to a small mixed-ingredient athlete study and animal studies, which we did not use. No trial of citrulline alone in healthy adults for memory turned up in our searches.
Can citrulline replace arginine in a supplement?
The body converts citrulline into arginine, which is why products carry both. That does not prove a memory effect from either. Arginine has one small oral pilot at 6.4 g a day; citrulline has none that we found.
Who wrote this
Written and reviewed by
Pages built from the label, the seller's brief and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is the information site of a USA Authorized MemoHoney Retailer. It is not the manufacturer, and the label names INSTITUTO EXPERIENCE (Ogden, Utah) as the distributor. We earn money when you buy through our order links.
Keep reading
More about MemoHoney
USA Authorized MemoHoney Retailer
Ready to look at MemoHoney?
Check your medicines first, especially nitrates, ED medicines and blood pressure medicines. Then pick a pack: 2, 3 or 6 bottles of 30 capsules. The checkout shows the price, the shipping and the money-back guarantee as printed there.
- Secure checkout on the seller's site
- Money-back guarantee, as printed at checkout
- Shipping shown at checkout